In order to realize the friction thermodynamic calculation of automotive ventilated disc brake that meets the conditions of heat production and heat transfer, the analytic method, experimental method and numerical simulation method are comprehensively used in the paper. The elastic-plastic state transition condition is analyzed by using micro convex theory, and the entropy balance equation is deduced based on an extensive amount of phenomenological equation. The flow control equation and the definite solution in two-dimensional space are concluded according to the boundary layer theory, and the multiplication method is come up for the three-dimensional heat transfer calculation. A new simulation method based on fluid-solid-thermal coupling calculation of ventilated disc brake is come up, and the synchronous iterative calculation based on MPCCI platform is finished by using ABAQUS for thermal-solid coupling and FLUENT for fluid-solid coupling. As a result, the transient temperature field, stress field and convective heat transfer coefficient are acquired with accurate boundary conditions. During the Link3900 NVH friction experiment result, it shows that the maximum temperature deviation between numerical simulation and experimental value is 5.6% in the braking cycle, which has obvious consistency, so the numerical simulation method is accurate and feasible.