Use the software of finite element analysis. Use Abaqus to analyze the influence on con-tact stress and Mises stress in different parameter of Polytetrafluoroethylene spring energized seal ring under ultrahigh pressure .The analysis shows :the Maximum Mises stress appear on the bottom of groove all the time; the size of posterior lip angle has direct influence on seal lip and the area of its contact surface, the proportion of the sealing lip and its contact surface decrease with the in-creasing of the angle. Cause the increasing of contact stress under same working pressure. In mo-tive seal, maximum contact stress fluctuating with time. The higher the speed, the greater the fluctuation is. Meanwhile stress concentration appears at lip when axle moves down. Friction coefficient has an effect on maximum contact stress Mises stress of the lip when axle moves down.